Lymphoepithelial carcinoma (LEC) is an uncommon malignant tumor composed of undifferentiated malignant epithelial cells with characteristic lymphoid stroma. The most common location of LEC is the nasopharynx.

What is nasopharynx carcinoma?

Nasopharyngeal carcinoma (also known as NPC) is a rare tumor of the head and neck which originates in the nasopharynx. The nasopharynx is located at the very back of the nose near the Eustachian tubes (Figure).

Is nasopharyngeal carcinoma A squamous cell carcinoma?

Nasopharyngeal carcinoma is an unusual neoplasm among squamous cell carcinomas of the head and neck. The tumor is rare in most parts of the world but is strikingly common in several Asian subpopulations, notably Chinese in Hong Kong and Guangdong Province.

What is Mucoepidermoid carcinoma?

Mucoepidermoid carcinoma Mucoepidermoid carcinomas are the most common type of salivary gland cancer. Most start in the parotid glands. They develop less often in the submandibular glands or in minor salivary glands inside the mouth. These cancers are usually low grade, but they can also be intermediate or high grade.

What is the best treatment for nasopharyngeal?

The main treatment for NPC is radiation therapy. It is often given in combination with chemotherapy. This approach may be called concomitant chemoradiotherapy. Surgery for NPC is occasionally used, mainly to remove lymph nodes after chemoradiotherapy or to treat NPC that has come back after initial treatment.

Is undifferentiated carcinoma curable?

When possible, the treatment is the complete removal of the tumor , combined with radiation therapy and chemotherapy . In cases where the tumor can’t be removed completely, the treatment is with radiation and chemotherapy. The risk of the tumor coming back (relapse) is high and the probability of cure is modest.

What is Lymphoepithelioma like carcinoma (LELC)?

Pulmonary lymphoepithelioma-like carcinoma (LELC) is an epithelial malignancy characterized by large, syncytial cells with vesicular nuclei and prominent nucleoli, with a prominent lymphocytic infiltrate LELC has a strong association with Epstein-Barr virus (EBV) and is more common in Asian populations

What is larynx lymphoepithelial carcinoma?

Laryngeal lymphoepithelial carcinoma is an extremely rare and an aggressive tumor. It is rarely associated with the EBV. It must be regarded as a distinct entity. Radiotherapy is advisable as the unique therapy for local tumor.

What is the pathophysiology of prominent lymphoplasmacytic infiltration?

Prominent lymphoplasmacytic infiltration predominantly composed of T lymphocytes; the inflammatory component can be very dense and obscure the squamous cell component, in which case cytokeratin stains may be needed