Function. The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil.

Is beta-catenin a protein?

Beta-catenin (β-catenin) is a multifunctional, 90 kD protein that contributes to cell development under normal physiological conditions [55]. β-Catenin is a crucial transcriptional factor in Wingless–Int (Wnt) signaling, and plays important role in stem cell renewal and organ regeneration [56].

What is AXIN2 gene mutation?

AXIN2 gene Overview Mutations in AXIN2 have been found in families where many individuals have large numbers of colorectal polyps and/or colorectal cancer. Individuals with AXIN2 mutations are believed to have a significantly increased risk for colorectal cancer, but the exact risk is not known.

How is β-catenin involved in cancer?

β-Catenin has been shown to upregulate urokinase plasminogen activator (uPA) expression in colorectal tumors to promote invasion, metastasis and dormancy in human colorectal tumors [97].

What does Mutyh stand for?

MUTYH (MYH)-associated polyposis (MAP) is a hereditary condition. People with MAP tend to develop multiple adenomatous colon polyps during their lifetime and will have an increased risk of colorectal cancer if they are not monitored closely with colonoscopies.

Is beta-catenin a proto oncogene?

Beta-catenin is a proto-oncogene. Mutations of this gene are commonly found in a variety of cancers: in primary hepatocellular carcinoma, colorectal cancer, ovarian carcinoma, breast cancer, lung cancer and glioblastoma.

What is B catenin in Wnt pathway?

The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of β-catenin in signal transduction. β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling.

Is β-catenin a druggable target for cancer therapy?

As an oncogenic transcription factor, β-catenin was conventionally considered as an undruggable target. However, recent discoveries of small molecules that directly bind to β-catenin suggest that β-catenin is a potentially druggable target that is yet to be drugged.

What does the Mutyh gene do?

The MUTYH gene provides instructions for making an enzyme called MYH glycosylase, which is involved in the repair of DNA. This enzyme corrects particular errors that are made when DNA is copied (DNA replication) in preparation for cell division.

What is the function of the Axin-related protein?

Function. The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin,…

What does AXIN2 stand for?

Axin-2 also known as axin-like protein (Axil) or axis inhibition protein 2 (AXIN2) or conductin is a protein that in humans is encoded by the AXIN2 gene.

What is the function of AXIN2 in Wnt?

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil.

What does the AXIN2 gene do in cancer?

The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]